The aim of this study was to assess changes in pupil size, uncorrected visual acuity, corrected visual acuity, subjective refraction, objective refraction, and the direct and consensual light reflexes after instillation of brimonidine 0.1% in the eyes of healthy subjects.ĭata presented as mean ± SD, unless otherwise indicated. Although previous studies have investigated pupil size, there have been no reports investigating a detailed description of direct and consensual light reflexes. Therefore, brimonidine inhibits pupil dilation under scotopic vision. The pupil size contracts under scotopic conditions is that brimonidine stimulates prejunctional alpha-2 agonist receptor and reduces norepinephrine release in the synapse. Brimonidine tartrate 0.2% and 0.15% ophthalmic solution has been reported to be significantly miotic under scotopic conditions 12, 13, and effective in reducing glare and halos after refractive surgery 14, 15. 11 reported that low-pressure glaucoma patients treated with brimonidine 0.2% are less likely to experience field progression. Brimonidine has been reported to have neuroprotective effect 9, 10. Therefore, it can be expected to provide effective intraocular pressure reduction in combination with other ophthalmic solutions. Brimonidine 0.2% peak ocular hypotensive effect occurs 2 h after instillation 7, and there was no significant difference from timolol maleate at the maximum effect 8. Its reduces intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow 5, 6. However, pilocarpine has been reported to cause excessive miosis, increased lens thickness, and adjustable tension from increases in transient myopia 4.īrimonidine, a selective alpha-2 adrenergic receptor agonist, is used in the treatment of glaucoma and ocular hypertension. Nighttime glare and halos have been reported to improve with miosis from pilocarpine hydrochloride. A reduction in night vision occurs due to increases in the high-order aberrations that occur with large pupils however, this may be improved by miosis 2, 3. Currently, concerns exist regarding these issues, which deteriorate visual performance and subsequent patient satisfaction. Brimonidine 0.1% induced a significant reduction in pupil size under scotopic conditions without a significant change in refraction or visual acuity due to suppression of the sympathetic nervous system.Īfter refractive surgery, patients may experience problems with nighttime glare and halos 1. The rate of pupil contraction and constriction speed measured by light reflexes were significantly increased at 1 h and 6 h after instillation ( P = 0.021 and P = 0.033, respectively). A significant reduction in pupil size was observed under scotopic conditions at 1 h and 6 h after instillation ( P = 0.007 and P = 0.005, respectively). We found No significant change was found in refraction or uncorrected visual acuity ( P = 0.999 and P = 0.998, respectively). Pupil size was measured quantitatively under photopic and scotopic conditions, uncorrected visual acuity, refraction, and direct and consensual light reflexes before and at 1, 6, and 24 h after instillation. The investigation comprised 46 eyes of 23 healthy subjects with no eye diseases in whom brimonidine 0.1% was instilled in the right eye. This study aimed to assess changes in pupil size, uncorrected visual acuity, refraction, and the direct and consensual light reflexes after instillation of brimonidine 0.1% in healthy subjects.
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